modelParacetamolComponents
Information
Whole body model of pharmacokinetic [1] with parameter of acetaminophen (paracetamol) recounted to appropriate params of the model[2].
[1] Jones, H. M., & Rowland-Yeo, K. (2013). Basic concepts in physiologically based pharmacokinetic modeling in drug discovery and development. CPT: Pharmacometrics and Systems Pharmacology, 2(8). https://doi.org/10.1038/psp.2013.41
[2] https://sepia2.unil.ch/pharmacology/drugs/paracetamol/
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacolibrary.Types.MassConcentration | cMin | 0.01 | minimum therapeutic concentration |
| Pharmacolibrary.Types.MassConcentration | cMax | 0.15 | maximum therapeutic concentration threshold for toxicity |
| Pharmacolibrary.Types.MassConcentration | cLethal | 0.3 | lethal concentration |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.Systems.WholeBody | wholeBody | ||
| Sources.PeriodicDose | periodicDose |