modelEq10RemdesivirPK
Information
Pharmacokinetic model of remdesivir with multiple (10) dosing implemented as simple PK equations.
[1] Leegwater E, et al. Population Pharmacokinetics of Remdesivir and GS-441524 in Hospitalized COVID-19 Patients. Antimicrob Agents Chemother. 2022.
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Real | F | 1 | Bioavailability (intravenously administered) |
| Integer | numDoses | 10 | Total number of doses |
| Real | doseFirst | 200*1e-6 | First dose (mg) |
| Real | doseSubsequent | 100*1e-6 | Subsequent doses (mg) |
| Real | dosingInterval | 86400 | Dosing interval in seconds (24 hours) |
| Real | t0 | 0 | Time of first dose (seconds) |
| Real | Vd | 271e-3 | Volume of distribution (L) |
| Real | Cl | 237e-3/3600 | Clearance (L/s) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacolibrary.Types.MassConcentration | C | Concentration | |
| Real | halfLife | ||
| Real[numDoses] | C_i | Concentration from each dose |