modelPK_1C_Gentamicin
Extends from Pharmacolibrary.Examples.PKOneCompartmentModel.
Information
Pharmacokinetic of Gentamicine - single compartment model example with parameter values of gentamicin, dosage 400 mg administered intravenously during 60s with bioavailability 1.Gentamicin is an aminoglycoside antibiotic used to treat serious bacterial infections, particularly those caused by Gram-negative organisms. Gentamicine is typically administered by intravenous (IV) or intramuscular (IM) injection in clinical settings, it is rapidly distributed in extracellular fluid and has limited tissue penetration. It's pharmacokinetics fits best single compartment model.
Simulation of 24h, drug administered at 1h:
References:
[1] Hodiamont, Caspar J et al. (2022-08). “Clinical pharmacokinetics of gentamicin in various patient populations and consequences for optimal dosing for Gram-negative infections: An updated review”. en. In: Clin. Pharmacokinet. 61.8, pp. 1075–1094. ISSN: 0312-5963,1179-1926. DOI: 10.1007/s40262 - 022 - 01143 - 0. URL: http://dx.doi.org/10.1007/s40262-022-01143-0
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacolibrary.Types.MassConcentration | MIC | 0.002 | Minimal inhibitory concentration |
| Pharmacolibrary.Types.MassConcentration | C_tox_peak | 0.012 | Peak toxicity concentration |
| Pharmacolibrary.Types.MassConcentration | C_tox_valley | 0.0021 | Peak toxicity concentration |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Sources.SingleDose | singleDose (from PKOneCompartmentModel) | ||
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PKOneCompartmentModel) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PKOneCompartmentModel) |