modelPK_1C_GentamicinEquations
Extends from Modelica.Icons.Example (Icon for runnable examples).
Information
Equivalent implementation of single compartment model using just equations with parameter values for gentamicine pharmacokinetics.Gentamicin is an aminoglycoside antibiotic used to treat serious bacterial infections, particularly those caused by Gram-negative organisms. Gentamicine is typically administered by intravenous (IV) or intramuscular (IM) injection in clinical settings, it is rapidly distributed in extracellular fluid and has limited tissue penetration. It's pharmacokinetics fits best single compartment model.
References:
[1] Hodiamont, Caspar J et al. (2022-08). “Clinical pharmacokinetics of gentamicin in various patient populations and consequences for optimal dosing for Gram-negative infections: An updated review”. en. In: Clin. Pharmacokinet. 61.8, pp. 1075–1094. ISSN: 0312-5963,1179-1926. DOI: 10.1007/s40262 - 022 - 01143 - 0. URL: http://dx.doi.org/10.1007/s40262-022-01143-0
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacolibrary.Types.Volume | Vd | 0.0175 | volume of distribution [m3] |
| Pharmacolibrary.Types.VolumeFlowRate | Cl | 0.0001/60 | elimination clearance [m3/s] |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacolibrary.Types.Mass | M | Mass of drug [kg] | |
| Pharmacolibrary.Types.MassConcentration | C | Concentration of drug | |
| Modelica.Units.SI.Time | t1_2 | elimination half-life |