modelPK_1C_GentamicineSimple

Diagram of PK_1C_GentamicineSimple

Extends from Pharmacolibrary.Examples.PKOneCompartmentSimplestModel.

Information

Pharmacokinetic of Gentamicine - single compartment model example with parameter values of gentamicin.

Gentamicin is an aminoglycoside antibiotic used to treat serious bacterial infections, particularly those caused by Gram-negative organisms. Gentamicine is typically administered by intravenous (IV) or intramuscular (IM) injection in clinical settings, it is rapidly distributed in extracellular fluid and has limited tissue penetration. It's pharmacokinetics fits best single compartment model. 

References:
[1] Hodiamont, Caspar J et al. (2022-08). “Clinical pharmacokinetics of gentamicin in various patient populations and consequences for optimal dosing for Gram-negative infections: An updated review”. en. In: Clin. Pharmacokinet. 61.8, pp. 1075–1094. ISSN: 0312-5963,1179-1926. DOI: 10.1007/s40262 - 022 - 01143 - 0. URL: http://dx.doi.org/10.1007/s40262-022-01143-0

Components

TypeNameDefaultDescription
Pharmacokinetic.NoPerfusedTissueCompartmentcentral (from PKOneCompartmentSimplestModel)
Pharmacokinetic.ClearanceDrivenEliminationelim (from PKOneCompartmentSimplestModel)