modelPK_2C_IVMidazolam
Extends from Pharmacolibrary.Examples.PKTwoCompartmentModel.
Information
Pharmacokinetic of Midazolam administered - 2-compartment model example with parameter values, dosage 9.6 mg administered intravenously with bioavailability 1.
Midazolam—a fast-acting benzodiazepine used for sedation, anxiolysis, and anesthesia induction—exemplifies a drug whose intravenous pharmacokinetics are well described by a two-compartment model. The plasma concentration requiredfor anesthesia induction must remain above a defined minimal effective threshold Cmin.
Simulation and experimental data from the paper of Heizmann et al. [1] from the subject O.A, as made open at https://pk-db.com/api/v1/subsets/5193/?format=json
[1] Heizmann, P., Eckert, M. and Ziegler, W. (1983), Pharmacokinetics and bioavailability of midazolam in man.. British Journal of Clinical Pharmacology, 16: 43S-49S. https://doi.org/10.1111/j.1365-2125.1983.tb02270.x
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacolibrary.Types.MassConcentration | Cmin | 6.3e-5 | |
| Pharmacolibrary.Types.MassConcentration | Cmax | 3e-4 |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacolibrary.Sources.PeriodicDose | periodicDose (from PKTwoCompartmentModel) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PKTwoCompartmentModel) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | central (from PKTwoCompartmentModel) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PKTwoCompartmentModel) | ||
| Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PKTwoCompartmentModel) | ||
| Modelica.Blocks.Sources.CombiTimeTable | CTT_MidazolamC | This is a validation from literature |
Revisions
- 05/2025 Tomas Kulhanek, initial model
- 05/2025 Filip Jezek, experimental data fit to model