modelPartialBloodTissueCompartment
Extends from Interfaces.InterfaceCompartment.
Information
The Partial Tissue compartments has two FlowPorts and one BloodTissueConcentrationPort connectors. It stores a mass of drug which is diluted in constant volume of blood/plamsa. It evaluates drug concentration, calculates mixing of inflow and contained blood/plasma of different drug concentrations and calculates change in drug amount due to transfer via the BloodTissueConcentrationPort.
If it is connected to other compartments via the BloodTissueConcentrationPort, there should be a transfer component inbetween.
C = M/V
CB = C/kTB
freeTissueConc = fu*C
freeBloodConc = fu*C/kTB
Variables
C - drug total concentration in tissue
CB - drug total concentration in blood/plasma
freeTissueConc - drug free concentration in tissue
freeBloodConc - drug free concentration in blood/plasma
M - drug total mass
Parameters
V - total distribution volume
C0 - drug initial concentration in tissue
kTB - tissue-blood concentration ratio
fu - fraction unbound
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Types.Volume | V | 0.001 | total distribution volume |
| Types.MassConcentration | C0 | 0 | drug initial concentration in tissue |
| Modelica.Units.SI.DimensionlessRatio | kTB | 1 | tissue-blood concentration ratio |
| Modelica.Units.SI.DimensionlessRatio | fu | 1 | fraction unbound |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| ConcentrationPort_a | cport (from InterfaceCompartment) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Types.MassConcentration | C | drug actual concentration in tissue | |
| Types.MassConcentration | CB | drug concentration in blood or plasma | |
| Types.MassConcentration | freeTissueConc | drug free concentration in tissue | |
| Types.MassConcentration | freeBloodConc | drug free concentration in blood or plasma | |
| Types.Mass | M | drug mass total | |
| Types.AreaUnderCurve | AUC | area under curve |