modelPartialCompartment
Extends from Pharmacolibrary.Interfaces.InterfaceCompartment.
Information
The Partial Compartment Tissue compartments has two FlowPorts and one BloodTissueConcentrationPort connectors. It stores a mass of drug which is diluted in constant volume of blood/plamsa. It evaluates drug concentration, calculates mixing of inflow and contained blood/plasma of different drug concentrations and calculates change in drug amount due to transfer via the BloodTissueConcentrationPort.
If it is connected to other compartments via the BloodTissueConcentrationPort, there should be a transfer component inbetween.
C = M/V
freeTissueConc = fu*C
Variables
C - drug total concentration in tissue
freeTissueConc - drug free concentration in tissue
M - drug total mass
Parameters
V - total distribution volume
C0 - drug initial concentration in tissue
fu - optional fraction unbound (default 1)
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacolibrary.Types.Volume | V | 0.001 | total distribution volume |
| Pharmacolibrary.Types.MassConcentration | C0 | 0 | drug initial concentration in tissue |
| Modelica.Units.SI.MolarMass | molarWeight | 1 | molar weight of molecule |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| ConcentrationPort_a | cport (from InterfaceCompartment) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.MolarConcentration | C_molar | molar concentration | |
| Pharmacolibrary.Types.MassConcentration | C | drug actual concentration in tissue | |
| Pharmacolibrary.Types.Mass | M | drug mass total | |
| Pharmacolibrary.Types.AreaUnderCurve | AUC | area under curve | |
| Pharmacolibrary.Types.MassConcentration | Cmax | ||
| Pharmacolibrary.Types.MassConcentration | Cmin |