modelFirstOrderStimulationEffect
indirect first order stimulation effect model
Extends from Pharmacolibrary.Interfaces.PartialIndirectEffect.
Information
FirstOrderStimulationEffect
indirect first order stimulation effect model. Effect E is calculated using an differential equation
Emax * c
E' = kIn - kOut*(1 + ----------)*E
c + c50
where c is the free concentration (either tissue or blood/plasma, depending on the switch) at the BloodTissueConcentrationPort connector.
Parameters
Emax - maximal effect
c50 - concentration producing 50% of maximum stimulation
kIn - zero-order response production constant
kOut - first-order response loss rate constant
Boolean cBSwitch - false: use tissue free conc, true: use blood free conc
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Real | kIn (from PartialIndirectEffect) | zero-order response production constant | |
| Real | kOut (from PartialIndirectEffect) | first-order response loss rate constant | |
| Real | Emax | maximal effect | |
| Pharmacolibrary.Types.MassConcentration | c50 | concentration producing 50% of maximum stimulation |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| ConcentrationPort_a | cport (from PartialEffect) | ||
| Modelica.Blocks.Interfaces.RealOutput | effect (from PartialEffect) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.DimensionlessRatio | E (from PartialEffect) | efect | |
| Pharmacolibrary.Types.MassConcentration | c (from PartialEffect) | free blood or tissue conc | |
| Real | IIn (from PartialIndirectEffect) | zero-order inhibition/stimulation factor | |
| Real | IOut (from PartialIndirectEffect) | first-order inhibition/stimulation factor |