modelSigmoidEmaxEffect
instant Sigmoid Emax effect
Extends from Pharmacolibrary.Interfaces.PartialEffect.
Information
SigmoidEmaxEffect
instant Sigmoid Emax effect model. Effect E is calculated using an equation
Emax * ch
E = E0 + -----------
c50h + ch
where c is the free concentration (either tissue or blood/plasma, depending on the switch) at the BloodTissueConcentrationPort connector.
Parameters
E0 - baseline effect without drug influence
Emax - maximal effect caused by drug
c50 - concentration producing half maximum effect
h - hill coefficient
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Real | E0 | 0 | baseline effect |
| Real | Emax | maximal effect | |
| Real | h | Hill exponent | |
| Pharmacolibrary.Types.MassConcentration | c50 | concentration producing 50% of Emax |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| ConcentrationPort_a | cport (from PartialEffect) | ||
| Modelica.Blocks.Interfaces.RealOutput | effect (from PartialEffect) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.DimensionlessRatio | E (from PartialEffect) | efect | |
| Pharmacolibrary.Types.MassConcentration | c (from PartialEffect) | free blood or tissue conc |