modelA03FA02
Extends from Pharmacokinetic.Models.PK_2C_enteral.
Information
| name: | Cisapride | |
| ATC code: | A03FA02 | route: | oral |
| compartments: | 2 | |
| dosage: | 10 | mg |
| volume of distribution: | 2.68 | L |
| clearance: | 0.39 | L/h/kg |
| other parameters in model implementation | ||
Cisapride is a gastroprokinetic agent that was used primarily to treat gastroesophageal reflux disease (GERD) and other gastrointestinal motility disorders. It acts as a serotonin 5-HT4 receptor agonist, stimulating acetylcholine release at enteric neurons to enhance gut motility. Due to its ability to cause serious cardiac arrhythmias (QT prolongation, torsades de pointes), cisapride has been withdrawn or restricted in many countries and is no longer widely approved for use.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult volunteers of both sexes receiving single oral doses of cisapride.
References
Caraballo, L, et al., & Marzi, M (2014). [Proarrhythmic effects of domperidone in infants: a systematic review]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 38(5) 438–444. DOI:10.7399/fh.2014.38.5.7957 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25344138
Kearns, GL, et al., & van den Anker, JN (2003). Cisapride disposition in neonates and infants: in vivo reflection of cytochrome P450 3A4 ontogeny. Clinical pharmacology and therapeutics 74(4) 312–325. DOI:10.1016/S0009-9236(03)00225-X PUBMED:https://pubmed.ncbi.nlm.nih.gov/14534518
Johnson, TN, et al., & Tucker, GT (2006). Prediction of the clearance of eleven drugs and associated variability in neonates, infants and children. Clinical pharmacokinetics 45(9) 931–956. DOI:10.2165/00003088-200645090-00005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16928154
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
| Pharmacolibrary.Types.TransferRate | ka (from PK_2C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_2C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)