modelPK_1C
Information
Generic 1-compartment model with simple periodic dosage modelled as zero order massflow during administration period - perfect for parental (intravenous or intraarterial) administration, less exact for oral administration.It has output concentration port.
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl | 20 | clearance |
| Modelica.Units.SI.Time | adminTime | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass | 1000 | administration mass (mg) |
| Integer | adminCount | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central | ||
| Interfaces.ConcentrationPort_b | centralCPort |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim | ||
| Sources.PeriodicDose | periodicDose | ||
| Modelica.Units.SI.Time | t1_2 | elimination half-life |