modelA03FA09
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Mosapride | |
| ATC code: | A03FA09 | route: | oral |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 4.9 | L |
| clearance: | 1.7 | L/h/kg |
| other parameters in model implementation | ||
Mosapride is a selective 5-HT4 receptor agonist used as a gastroprokinetic agent to treat symptoms of gastroesophageal reflux disease (GERD) and functional dyspepsia. It enhances gastrointestinal motility by stimulating the release of acetylcholine in the enteric nervous system. Mosapride is approved for use in several countries for the management of gastrointestinal disorders related to delayed gastric emptying.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult male volunteers following a single oral administration.
References
Chae, JW, et al., & Kwon, KI (2015). Determination of influence of food intake after a single oral dose of mosapride in beagle dogs using nonlinear mixed effect modeling. Journal of veterinary pharmacology and therapeutics 38(6) 590–595. DOI:10.1111/jvp.12228 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25955782
Hamatani, T, et al., & Fujio, Y (2020). Thorough QT/QTc Study Shows That a Novel 5-HT. Clinical pharmacology in drug development 9(8) 938–951. DOI:10.1002/cpdd.778 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32087003
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)