modelA06AC07
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | TriticumWheatFibre | |
| ATC code: | A06AC07 | route: | oral |
| compartments: | 1 | |
| dosage: | 5000 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | L/h |
| other parameters in model implementation | ||
Triticum (wheat fibre) is a dietary fibre derived from wheat, classified as a bulk-forming laxative. It is used to treat constipation and to promote bowel regularity by increasing stool bulk. It is available as an over-the-counter supplement and is considered safe for general use, though not indicated for acute or severe constipation or in patients with intestinal obstruction. It is approved for use as a dietary supplement rather than as a prescription medication.
Pharmacokinetics
No published pharmacokinetic studies reporting absorption, distribution, metabolism, or excretion of wheat fibre as an active pharmacologically absorbed substance in humans. Dietary fibre is generally considered non-absorbable; pharmacokinetic parameters such as volume of distribution, clearance, and bioavailability are not typically defined for this agent.
References
Marklund, M, et al., & Kamal-Eldin, A (2013). Chain length of dietary alkylresorcinols affects their in vivo elimination kinetics in rats. The Journal of nutrition 143(10) 1573–1578. DOI:10.3945/jn.113.178392 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23946349
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)