modelA07AA04
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Streptomycin | |
| ATC code: | A07AA04 | route: | intramuscular |
| compartments: | 1 | |
| dosage: | 1000 | mg |
| volume of distribution: | 0.26 | L |
| clearance: | 1.4 | ml/min/kg |
| other parameters in model implementation | ||
Streptomycin is an aminoglycoside antibiotic used to treat a variety of gram-negative and some gram-positive bacterial infections, notably tuberculosis. It is typically reserved for use in cases of tuberculosis and other specific infections due to resistance or intolerance to other agents. Streptomycin was historically very important but is now less commonly used due to the availability of newer antibiotics and risk of side effects.
Pharmacokinetics
Pharmacokinetic parameters in healthy adult subjects following a single intramuscular dose.
References
Zhu, M, et al., & Peloquin, CA (2001). Population pharmacokinetics of intravenous and intramuscular streptomycin in patients with tuberculosis. Pharmacotherapy 21(9) 1037–1045. DOI:10.1592/phco.21.13.1037.34625 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11560193
Alffenaar, JW, et al., & van der Werf, TS (2010). Pharmacokinetics of rifampin and clarithromycin in patients treated for Mycobacterium ulcerans infection. Antimicrobial agents and chemotherapy 54(9) 3878–3883. DOI:10.1128/AAC.00099-10 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20585115
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)