modelA07AA10
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Colistin | |
| ATC code: | A07AA10 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 150 | mg |
| volume of distribution: | 13.6 | L |
| clearance: | 2.4 | L/h |
| other parameters in model implementation | ||
Colistin, also known as polymyxin E, is a polymyxin antibiotic used for the treatment of infections caused by multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumoniae. It is often used as a last-resort antibiotic in severely ill patients and is administered intravenously as colistin methanesulfonate (CMS), which is an inactive prodrug converted in vivo to the active colistin. Colistin is approved and in clinical use today, but its use is limited by nephrotoxicity and neurotoxicity.
Pharmacokinetics
Pharmacokinetic parameters for intravenous administration of colistin methanesulfonate in adult critically ill patients. Values are typical for a two-compartment model.
References
Xie, YL, et al., & Peng, Y (2022). Population pharmacokinetics of intravenous colistin sulfate and dosage optimization in critically ill patients. Frontiers in pharmacology 13 967412–None. DOI:10.3389/fphar.2022.967412 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36105229
Nation, RL, et al., & Silveira, FP (2017). Dosing guidance for intravenous colistin in critically-ill patients. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 64(5) 565–571. DOI:10.1093/cid/ciw839 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28011614
Ooi, MH, et al., & Nation, RL (2019). Population Pharmacokinetics of Intravenous Colistin in Pediatric Patients: Implications for the Selection of Dosage Regimens. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 69(11) 1962–1968. DOI:10.1093/cid/ciz067 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30722017
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)