modelA07AA12
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Fidaxomicin | |
| ATC code: | A07AA12 | route: | oral |
| compartments: | 1 | |
| dosage: | 200 | mg |
| volume of distribution: | 46 | L |
| clearance: | 13 | L/h |
| other parameters in model implementation | ||
Fidaxomicin is a narrow-spectrum macrocyclic antibiotic used primarily for the treatment of Clostridioides difficile-associated diarrhea. It is approved for use in adults and children and exhibits minimal systemic absorption, acting mainly in the gastrointestinal tract.
Pharmacokinetics
Pharmacokinetics reported in healthy adult volunteers following oral administration.
References
Daniels, T, & So, TY (2011). Fidaxomicin for the Treatment of Clostridium Difficile Infection in the Pediatric Population - Not Quite So Soon Yet. Gastroenterology research 4(3) 93–96. DOI:10.4021/gr318e PUBMED:https://pubmed.ncbi.nlm.nih.gov/27942322
Skinner, AM, et al., & Kociolek, LK (2020). Fidaxomicin for the treatment of . Future microbiology 15(11) 967–979. DOI:10.2217/fmb-2020-0104 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32715754
Vande Griend, JP, et al., & Linnebur, SA (2012). A year in review: new drugs for older adults in 2011. The American journal of geriatric pharmacotherapy 10(4) 258–263. DOI:10.1016/j.amjopharm.2012.05.003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22682643
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)