modelA10AB04
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | InsulinLispro | |
| ATC code: | A10AB04 | route: | subcutaneous |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 0.048 | L |
| clearance: | 1.21 | L/h/kg |
| other parameters in model implementation | ||
Insulin lispro is a rapid-acting human insulin analogue used primarily in the management of diabetes mellitus to control postprandial blood glucose levels. It is approved for use today in both type 1 and type 2 diabetes to achieve better glycemic control.
Pharmacokinetics
Pharmacokinetic parameters observed in healthy adult subjects (both male and female) following subcutaneous administration.
References
de la Peña, A, et al., & Ignaut, DA (2015). Subcutaneous Injection Depth Does Not Affect the Pharmacokinetics or Glucodynamics of Insulin Lispro in Normal Weight or Healthy Obese Subjects. Journal of diabetes science and technology 9(4) 824–830. DOI:10.1177/1932296815573865 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25697717
Chao, M, et al., & Ning, G (2010). Bioequivalence between two human insulin analogs in Chinese population: Glulisine and Lispro. Endocrine 38(1) 48–52. DOI:10.1007/s12020-010-9326-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20960101
Shiramoto, M, et al., & Ohwaki, K (2020). Ultra-Rapid Lispro results in accelerated insulin lispro absorption and faster early insulin action in comparison with Humalog. Journal of diabetes investigation 11(3) 672–680. DOI:10.1111/jdi.13195 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31816193
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)