modelA10AC04
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | InsulinLispro | |
| ATC code: | A10AC04 | route: | subcutaneous |
| compartments: | 1 | |
| dosage: | 10 | mg |
| volume of distribution: | 0.23 | L |
| clearance: | 1.2 | L/h |
| other parameters in model implementation | ||
Insulin lispro is a rapid-acting human insulin analog used to improve glycemic control in patients with diabetes mellitus. It acts quickly to lower blood glucose levels and is typically administered immediately before meals. Insulin lispro is approved and widely used in current diabetic management, both for type 1 and type 2 diabetes.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult subjects after single subcutaneous injection.
References
de la Peña, A, et al., & Ignaut, DA (2015). Subcutaneous Injection Depth Does Not Affect the Pharmacokinetics or Glucodynamics of Insulin Lispro in Normal Weight or Healthy Obese Subjects. Journal of diabetes science and technology 9(4) 824–830. DOI:10.1177/1932296815573865 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25697717
Chao, M, et al., & Ning, G (2010). Bioequivalence between two human insulin analogs in Chinese population: Glulisine and Lispro. Endocrine 38(1) 48–52. DOI:10.1007/s12020-010-9326-4 PUBMED:https://pubmed.ncbi.nlm.nih.gov/20960101
Shiramoto, M, et al., & Ohwaki, K (2020). Ultra-Rapid Lispro results in accelerated insulin lispro absorption and faster early insulin action in comparison with Humalog. Journal of diabetes investigation 11(3) 672–680. DOI:10.1111/jdi.13195 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31816193
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)