modelA10BD01
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | PhenforminAndSulfonylureas | |
| ATC code: | A10BD01 | route: | oral |
| compartments: | 1 | |
| dosage: | 50 | mg |
| volume of distribution: | 1.5 | L |
| clearance: | 200 | mL/min |
| other parameters in model implementation | ||
Phenformin and sulfonylureas (ATC code A10BD01) is a fixed-dose combination previously used in the management of type 2 diabetes mellitus. Phenformin is a biguanide-class antihyperglycemic agent, while sulfonylureas stimulate insulin secretion from pancreatic beta cells. Phenformin was withdrawn in many countries due to risk of lactic acidosis, and the combination is not currently approved or in regular clinical use.
Pharmacokinetics
No published pharmacokinetic model with quantitative parameters for the fixed-dose combination phenformin and sulfonylureas with ATC code A10BD01 was found. Thus, no referenced population pharmacokinetic data are available. Estimates here are based on typical oral pharmacokinetics for each drug class separately and assumed for the combination, with standard adult population as target.
References
Scheen, AJ, & Lefèbvre, PJ (1995). Antihyperglycaemic agents. Drug interactions of clinical importance. Drug safety 12(1) 32–45. DOI:10.2165/00002018-199512010-00003 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7741982
Marchetti, P, et al., & Navalesi, R (1991). Pharmacokinetic optimisation of oral hypoglycaemic therapy. Clinical pharmacokinetics 21(4) 308–317. DOI:10.2165/00003088-199121040-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1760902
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)