modelA16AX03
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | SodiumPhenylbutyrate | |
| ATC code: | A16AX03 | route: | oral |
| compartments: | 1 | |
| dosage: | 500 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 5.0 | L/h |
| other parameters in model implementation | ||
Sodium phenylbutyrate is an aromatic fatty acid used as a nitrogen scavenger in the management of urea cycle disorders (UCDs). By promoting excretion of excess nitrogen, it is used to treat hyperammonemia due to enzyme deficiencies in the urea cycle. It is an FDA-approved therapy for this indication, and also investigated for possible adjunctive use in other rare metabolic diseases and disorders involving ammonia toxicity.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers, both sexes, after a single oral dose under fasting conditions.
References
Phuphanich, S, et al., & Carducci, MA (2005). Oral sodium phenylbutyrate in patients with recurrent malignant gliomas: a dose escalation and pharmacologic study. Neuro-oncology 7(2) 177–182. DOI:10.1215/S1152851704000183 PUBMED:https://pubmed.ncbi.nlm.nih.gov/15831235
Bireley, JD, & Morren, JA (2023). CNM-Au8: an experimental agent for the treatment of amyotrophic lateral sclerosis (ALS). Expert opinion on investigational drugs 32(8) 677–683. DOI:10.1080/13543784.2023.2252738 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37642362
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)