modelB01AA07
Extends from Pharmacokinetic.Models.PK_2C_enteral.
Information
| name: | Acenocoumarol | |
| ATC code: | B01AA07 | route: | oral |
| compartments: | 2 | |
| dosage: | 8 | mg |
| volume of distribution: | 0.125 | L |
| clearance: | 2.1 | L/h |
| other parameters in model implementation | ||
Acenocoumarol is a vitamin K antagonist oral anticoagulant, structurally related to warfarin, used for the prevention and treatment of thromboembolic disorders such as deep vein thrombosis, pulmonary embolism, and for stroke prevention in atrial fibrillation. It is approved and used in several countries, though not in the United States.
Pharmacokinetics
Reported pharmacokinetic parameters in healthy adult volunteers after oral administration.
References
Thijssen, HH, et al., & de Vries-Hanje, JC (2001). Altered pharmacokinetics of R- and S-acenocoumarol in a subject heterozygous for CYP2C9*3. Clinical pharmacology and therapeutics 70(3) 292–298. DOI:10.1067/mcp.2001.117936 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11557918
Stehle, S, et al., & Fuhr, U (2008). Pharmacogenetics of oral anticoagulants: a basis for dose individualization. Clinical pharmacokinetics 47(9) 565–594. DOI:10.2165/00003088-200847090-00002 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18698879
Villapalos-García, G, et al., & Abad-Santos, F (2023). NAT2 phenotype alters pharmacokinetics of rivaroxaban in healthy volunteers. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 165 115058–None. DOI:10.1016/j.biopha.2023.115058 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37385211
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
| Pharmacolibrary.Types.TransferRate | ka (from PK_2C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_2C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)