modelB01AA12
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Fluindione | |
| ATC code: | B01AA12 | route: | oral |
| compartments: | 1 | |
| dosage: | 20 | mg |
| volume of distribution: | 10 | L |
| clearance: | 0.14 | L/h |
| other parameters in model implementation | ||
Fluindione is a vitamin K antagonist anticoagulant (coumarin derivative) that was historically used for the prevention and treatment of thromboembolic disorders, such as deep vein thrombosis and pulmonary embolism. It has been largely withdrawn or replaced by other anticoagulants in most countries and is not widely used today.
Pharmacokinetics
Pharmacokinetic parameters estimated for a typical adult following oral administration (estimates; no referenced clinical PK source found).
References
Mentré, F, et al., & Lechat, P (1998). Population pharmacokinetic-pharmacodynamic analysis of fluindione in patients. Clinical pharmacology and therapeutics 63(1) 64–78. DOI:10.1016/S0009-9236(98)90122-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9465843
Comets, E, et al., & Mentré, F (2012). Pharmacokinetic and pharmacodynamic variability of fluindione in octogenarians. Clinical pharmacology and therapeutics 91(5) 777–786. DOI:10.1038/clpt.2011.309 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22472992
Verstuyft, C, et al., & Becquemont, L (2012). A pharmacokinetic-pharmacodynamic model for predicting the impact of CYP2C9 and VKORC1 polymorphisms on fluindione and acenocoumarol during induction therapy. Clinical pharmacokinetics 51(1) 41–53. DOI:10.2165/11595560-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/22149257
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)