modelB01AB04
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Dalteparin | |
| ATC code: | B01AB04 | route: | subcutaneous |
| compartments: | 1 | |
| dosage: | 5000 | mg |
| volume of distribution: | 0.07 | L |
| clearance: | 1.68 | mL/min/kg |
| other parameters in model implementation | ||
Dalteparin is a low molecular weight heparin (LMWH) used as an anticoagulant for the prevention and treatment of deep vein thrombosis, pulmonary embolism, and for prophylaxis in patients undergoing surgery or at increased risk of thromboembolic events. It is approved and widely used today for these indications.
Pharmacokinetics
Pharmacokinetic parameters in healthy adult volunteers (both male and female) after single subcutaneous injection.
References
Damle, B, et al., & Sweeney, K (2021). Population Pharmacokinetic Analysis of Dalteparin in Pediatric Patients With Venous Thromboembolism. Journal of clinical pharmacology 61(2) 172–180. DOI:10.1002/jcph.1716 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32827160
Howard, PA (1997). Dalteparin: a low-molecular-weight heparin. The Annals of pharmacotherapy 31(2) 192–203. DOI:10.1177/106002809703100212 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9034422
Yu, L, et al., & Guo, R (2018). Pharmacodynamic properties and bioequivalence of dalteparin sodium subcutaneous injection in healthy Chinese male subjects. Xenobiotica; the fate of foreign compounds in biological systems 48(4) 376–381. DOI:10.1080/00498254.2017.1316021 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28375032
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)