modelB01AB05
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Enoxaparin | |
| ATC code: | B01AB05 | route: | subcutaneous |
| compartments: | 1 | |
| dosage: | 40 | mg |
| volume of distribution: | 4.3 | L |
| clearance: | 0.21 | L/h |
| other parameters in model implementation | ||
Enoxaparin is a low molecular weight heparin (LMWH) used primarily for the prevention and treatment of deep vein thrombosis (DVT), pulmonary embolism (PE), and acute coronary syndromes. It works by inhibiting factor Xa and is widely approved and used in clinical practice for anticoagulation.
Pharmacokinetics
Pharmacokinetics in healthy adult subjects following subcutaneous injection.
References
Moffett, BS, et al., & Yee, D (2018). Population Pharmacokinetics of Enoxaparin in Pediatric Patients. The Annals of pharmacotherapy 52(2) 140–146. DOI:10.1177/1060028017734234 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28962537
Carreño, FO, et al., & Gonzalez, D (2024). Characterizing Enoxaparin's Population Pharmacokinetics to Guide Dose Individualization in the Pediatric Population. Clinical pharmacokinetics 63(7) 999–1014. DOI:10.1007/s40262-024-01388-x PUBMED:https://pubmed.ncbi.nlm.nih.gov/38955947
Frum, J, et al., & Thomason, J (2022). Anticoagulant profile of subcutaneous enoxaparin in healthy dogs. Journal of veterinary pharmacology and therapeutics 45(1) 34–45. DOI:10.1111/jvp.13015 PUBMED:https://pubmed.ncbi.nlm.nih.gov/34622463
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)