modelB02BC07
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Collagen | |
| ATC code: | B02BC07 | route: | topical |
| compartments: | 0 | |
| dosage: | 1 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
Collagen is a structural protein widely used as a hemostatic agent in surgery, wound healing, and dental procedures. Pharmaceutical collagen preparations are derived mainly from bovine or porcine sources. Currently, it is used as a topical or local agent for bleeding control and tissue support, but is not an active systemic pharmaceutical and is not approved as such.
Pharmacokinetics
No systemic pharmacokinetic (PK) data are reported for collagen as a pharmaceutical agent, as it is generally used topically or locally and not intended for systemic absorption. As such, standard pharmacokinetic parameters (such as volume of distribution, clearance, and absorption rates) are not established in the literature.
References
Peirano, RI, et al., & Blatt, T (2011). Dermal penetration of creatine from a face-care formulation containing creatine, guarana and glycerol is linked to effective antiwrinkle and antisagging efficacy in male subjects. Journal of cosmetic dermatology 10(4) 273–281. DOI:10.1111/j.1473-2165.2011.00579.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/22151935
Graham, JS, et al., & Schiavetta, AM (2009). Medical management of cutaneous sulfur mustard injuries. Toxicology 263(1) 47–58. DOI:10.1016/j.tox.2008.07.067 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18762227
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)