modelB03BB01
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | FolicAcid | |
| ATC code: | B03BB01 | route: | oral |
| compartments: | 1 | |
| dosage: | 5 | mg |
| volume of distribution: | 7.0 | L |
| clearance: | 204 | mL/min |
| other parameters in model implementation | ||
Folic acid (vitamin B9) is a water-soluble B vitamin used for the prevention and treatment of folate deficiency, including in conditions such as anemia, during pregnancy to prevent neural tube defects, and in certain methotrexate toxicities. It is widely available as an oral supplement and approved for use today.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers following a single oral dose of folic acid.
References
Lee, SK (2023). Issues of Women with Epilepsy and Suitable Antiseizure Drugs. Journal of epilepsy research 13(2) 23–35. DOI:10.14581/jer.23005 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38223363
Genton, P, et al., & Trinka, E (2006). Valproic acid in epilepsy : pregnancy-related issues. Drug safety 29(1) 1–21. DOI:10.2165/00002018-200629010-00001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/16454531
Bayes, J, et al., & Schloss, J (2019). The Bioavailability of Various Oral Forms of Folate Supplementation in Healthy Populations and Animal Models: A Systematic Review. Journal of alternative and complementary medicine (New York, N.Y.) 25(2) 169–180. DOI:10.1089/acm.2018.0086 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30010385
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)