modelB05AA05
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Dextran | |
| ATC code: | B05AA05 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 75000 | mg |
| volume of distribution: | 6.4 | L |
| clearance: | 23.0 | mL/min |
| other parameters in model implementation | ||
Dextran is a complex branched polysaccharide used as a plasma volume expander for hypovolemia and in some cases to improve blood flow and prevent thrombosis. It has been used particularly in settings of blood loss or shock, but its use has declined as safer alternatives have become available. Dextran is still used in clinical practice in some countries, mostly as Dextran 40 or Dextran 70 intravenous solutions.
Pharmacokinetics
Intravenous dextran (Dextran 70) pharmacokinetics in adult human volunteers; typical parameters after infusion of 1000 mg/kg.
References
Muñoz, M, et al., & García-Erce, JA (2009). Intravenous iron in inflammatory bowel disease. World journal of gastroenterology 15(37) 4666–4674. DOI:10.3748/wjg.15.4666 PUBMED:https://pubmed.ncbi.nlm.nih.gov/19787830
Rizk, DV, et al., & Molitoris, BA (2018). A Novel Method for Rapid Bedside Measurement of GFR. Journal of the American Society of Nephrology : JASN 29(6) 1609–1613. DOI:10.1681/ASN.2018020160 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29748326
Yang, Y, et al., & Balthasar, JP (2017). Investigation of the Influence of Protein-Losing Enteropathy on Monoclonal Antibody Pharmacokinetics in Mice. The AAPS journal 19(6) 1791–1803. DOI:10.1208/s12248-017-0135-z PUBMED:https://pubmed.ncbi.nlm.nih.gov/28849396
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)