modelB05AX01
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Erythrocytes | |
| ATC code: | B05AX01 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 1 | mg |
| volume of distribution: | 4.5 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
Erythrocytes, or red blood cells, are administered as blood transfusions to treat or prevent anemia resulting from blood loss, surgery, or various medical conditions. They increase the oxygen-carrying capacity of blood. Erythrocyte transfusions are approved and routinely used in clinical medicine.
Pharmacokinetics
No conventional pharmacokinetic parameters (e.g., volume of distribution, clearance, etc.) are defined for erythrocytes as they are cellular components rather than typical chemical drugs. Their in vivo fate is governed by cell survival, sequestration, and destruction primarily in the spleen and liver. Typical pharmacokinetic modeling is not applicable.
References
Janssen, JM, et al., & Huitema, ADR (2020). A Semi-Mechanistic Population Pharmacokinetic/Pharmacodynamic Model of Bortezomib in Pediatric Patients with Relapsed/Refractory Acute Lymphoblastic Leukemia. Clinical pharmacokinetics 59(2) 207–216. DOI:10.1007/s40262-019-00803-y PUBMED:https://pubmed.ncbi.nlm.nih.gov/31313068
Snoeck, E, et al., & Heykants, J (1997). Population analysis of the non linear red blood cell partitioning and the concentration-effect relationship of draflazine following various infusion rates. British journal of clinical pharmacology 43(6) 603–612. DOI:10.1046/j.1365-2125.1997.00593.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/9205820
Goggs, R, & Behling-Kelly, E (2019). C. BMC veterinary research 15(1) 475–None. DOI:10.1186/s12917-019-2220-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31888626
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)