modelB05AX04
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | StemCellsFromUmbilicalCordBlood | |
| ATC code: | B05AX04 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 1 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
Stem cells from umbilical cord blood are hematopoietic progenitor cells harvested from the blood of the umbilical cord at birth. They are used primarily for hematopoietic stem cell transplantation and regenerative medicine, often to treat disorders such as leukemia, lymphoma, and some genetic blood diseases. This is an approved therapy in many countries for these indications.
Pharmacokinetics
No published pharmacokinetic parameters are available for stem cells from umbilical cord blood, as stem cell therapies involve living cells with complex biodistribution, engraftment, and persistence properties rather than conventional ADME pharmacokinetics typical of small molecule drugs. Literature does not report standard PK parameters for cell-based therapies in intravenous infusion in pediatric or adult subjects.
References
Oliver-Vila, I, et al., & Vives, J (2016). Evaluation of a cell-banking strategy for the production of clinical grade mesenchymal stromal cells from Wharton's jelly. Cytotherapy 18(1) 25–35. DOI:10.1016/j.jcyt.2015.10.001 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26549383
Corenblum, MJ, et al., & Madhavan, L (2015). Systemic human CD34(+) cells populate the brain and activate host mechanisms to counteract nigrostriatal degeneration. Regenerative medicine 10(5) 563–577. DOI:10.2217/rme.15.32 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26237701
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)