modelB05BB01
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Electrolytes | |
| ATC code: | B05BB01 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 1000 | mg |
| volume of distribution: | 17 | L |
| clearance: | 70 | ml/min |
| other parameters in model implementation | ||
Electrolytes with ATC code B05BB01 are intravenous solutions containing various combinations of essential ions such as sodium, potassium, calcium, magnesium, chloride, and bicarbonate. They are commonly used for fluid and electrolyte replenishment in cases of dehydration, electrolyte imbalance, and during surgery or intensive care. These solutions are widely approved and are a mainstay in clinical practice to restore or maintain normal electrolyte balance.
Pharmacokinetics
There are no specific pharmacokinetic models or parameter publications describing the multi-electrolyte solutions as a whole because each ion component (e.g., sodium, potassium) follows its own physiological kinetics, and product formulations vary widely. Pharmacokinetic parameters are therefore not directly applicable to 'electrolytes' as a combined drug entity.
References
Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703
Cunningham, D, et al., & Russell, RI (1985). Functional and structural changes of the human proximal small intestine after cytotoxic therapy. Journal of clinical pathology 38(3) 265–270. DOI:10.1136/jcp.38.3.265 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3919064
Brashier, MK, et al., & O'Leary, TP (1998). Effect of intravenous calcium administration on gentamicin-induced nephrotoxicosis in ponies. American journal of veterinary research 59(8) 1055–1062. PUBMED:https://pubmed.ncbi.nlm.nih.gov/9706213
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)