modelB05CX01
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Glucose | |
| ATC code: | B05CX01 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 25000 | mg |
| volume of distribution: | 10 | L |
| clearance: | 120 | mL/min |
| other parameters in model implementation | ||
Glucose is a monosaccharide sugar that serves as the main source of energy for the body's cells. It is used intravenously as a source of calories and fluid in patients unable to eat or drink, for treatment of hypoglycemia, dehydration, or during parenteral nutrition. Glucose is approved and widely used in clinical practice.
Pharmacokinetics
Pharmacokinetic parameters reported for healthy adult subjects after intravenous administration of glucose.
References
Graham, GG, et al., & Williams, KM (2011). Clinical pharmacokinetics of metformin. Clinical pharmacokinetics 50(2) 81–98. DOI:10.2165/11534750-000000000-00000 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21241070
Alshaer, MH, et al., & Hosmann, A (2022). Meropenem Population Pharmacokinetics and Simulations in Plasma, Cerebrospinal Fluid, and Brain Tissue. Antimicrobial agents and chemotherapy 66(8) e0043822–None. DOI:10.1128/aac.00438-22 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35862739
Ng, CM, et al., & De León, DD (2018). Population pharmacokinetics of exendin-(9-39) and clinical dose selection in patients with congenital hyperinsulinism. British journal of clinical pharmacology 84(3) 520–532. DOI:10.1111/bcp.13463 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29077992
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)