modelB05XA03
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | SodiumChloride | |
| ATC code: | B05XA03 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 9000 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 1 | mL/min/kg |
| other parameters in model implementation | ||
Sodium chloride (NaCl), also known as table salt, is an essential electrolyte used in medicine primarily for fluid and electrolyte replenishment. It is administered as isotonic or hypertonic solutions for the treatment of dehydration, hyponatremia, metabolic alkalosis, and as a vehicle for the delivery of other medications. Sodium chloride solutions are widely approved and used today in various clinical settings.
Pharmacokinetics
PK parameters for intravenous administration in healthy adults, typical clinical setting.
References
Parker, SL, et al., & Roberts, JA (2018). Population pharmacokinetics of intravenous paracetamol in critically ill patients with traumatic brain injury. Journal of critical care 47 15–20. DOI:10.1016/j.jcrc.2018.05.016 PUBMED:https://pubmed.ncbi.nlm.nih.gov/29883885
Liu, Y, et al., & Wang, X (2023). Pharmacokinetics and safety of injected ornidazole compared to its enantiomer levornidazole in healthy Chinese subjects. International journal of clinical pharmacology and therapeutics 61(12) 543–550. DOI:10.5414/CP204442 PUBMED:https://pubmed.ncbi.nlm.nih.gov/37840522
Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)