modelB05XA05
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | MagnesiumSulfate | |
| ATC code: | B05XA05 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 4000 | mg |
| volume of distribution: | 13.65 | L |
| clearance: | 4.45 | L/h |
| other parameters in model implementation | ||
Magnesium sulfate is an inorganic salt used in medicine for multiple applications, including the management of eclampsia and pre-eclampsia in obstetrics, as a tocolytic agent, for treating magnesium deficiency, and as an adjunct in severe asthma exacerbations. It is approved and widely used today, primarily by intravenous administration in clinical settings.
Pharmacokinetics
Pharmacokinetics reported in healthy adult volunteers, both male and female, after intravenous administration of magnesium sulfate.
References
da Costa, TX, et al., & Oliveira, AG (2020). Population Pharmacokinetics of Magnesium Sulfate in Preeclampsia and Associated Factors. Drugs in R&D 20(3) 257–266. DOI:10.1007/s40268-020-00315-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/32642964
Brookfield, KF, et al., & Carvalho, B (2016). Pharmacokinetics and placental transfer of magnesium sulfate in pregnant women. American journal of obstetrics and gynecology 214(6) 737.e1–737.e7379. DOI:10.1016/j.ajog.2015.12.060 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26767791
Rower, JE, et al., & Finkelstein, Y (2025). Pharmacokinetics and Pharmacodynamics of Intravenous Magnesium Sulfate in Pediatric Acute Asthma Exacerbations. Journal of clinical pharmacology 65(6) 665–674. DOI:10.1002/jcph.6179 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39775569
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)