modelB05XA13
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | HydrochloricAcid | |
| ATC code: | B05XA13 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 0.3 | L |
| clearance: | 0 | |
| other parameters in model implementation | ||
Hydrochloric acid is a strong inorganic acid that is naturally present in the gastric juice of the human stomach, aiding in digestion and maintaining the acidic pH. As a drug, its main use is as a component in intravenous nutritional solutions to adjust pH or to treat severe metabolic alkalosis. It is not commonly used as a stand-alone therapeutic agent and is not an approved drug for most pharmacological indications in modern practice.
Pharmacokinetics
No pharmacokinetic studies in human subjects describing absorption, distribution, metabolism, and excretion have been published because hydrochloric acid is a naturally present and rapidly neutralized/ionized substance in body fluids. Parameters below are not reported in primary literature.
References
Brooks, EC, et al., & Terada, LS (1997). Nitric oxide attenuates and xanthine oxidase exaggerates lung damage-induced gut injury. The American journal of physiology 272(4 Pt 1) G845–G852. DOI:10.1152/ajpgi.1997.272.4.G845 PUBMED:https://pubmed.ncbi.nlm.nih.gov/9142917
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)