modelB06AA55
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | StreptokinaseCombinations | |
| ATC code: | B06AA55 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 1500000 | mg |
| volume of distribution: | 0.12 | L |
| clearance: | 3.8 | mL/min/kg |
| other parameters in model implementation | ||
Streptokinase in combination form is a fibrinolytic drug used to dissolve blood clots in medical conditions such as acute myocardial infarction and pulmonary embolism. It works by activating plasminogen to produce plasmin, which degrades fibrin clots. Streptokinase combinations are used in emergencies to restore blood flow. Streptokinase is not commonly used today due to antibody formation and availability of newer agents, but it remains available in some countries.
Pharmacokinetics
Pharmacokinetic parameters estimated for streptokinase combinations based on published data for streptokinase administration in adult patients with acute myocardial infarction. Parameters assumed similar due to lack of direct publications on combinations.
References
Battershill, PE, et al., & Goa, KL (1994). Streptokinase. A review of its pharmacology and therapeutic efficacy in acute myocardial infarction in older patients. Drugs & aging 4(1) 63–86. DOI:10.2165/00002512-199404010-00007 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8130384
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)