modelC01BB02
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Mexiletine | |
| ATC code: | C01BB02 | route: | oral |
| compartments: | 1 | |
| dosage: | 200 | mg |
| volume of distribution: | 5.5 | L |
| clearance: | 0.7 | L/h/kg |
| other parameters in model implementation | ||
Mexiletine is a class IB antiarrhythmic drug primarily used to treat ventricular arrhythmias, such as ventricular tachycardia. It is a sodium channel blocker structurally related to lidocaine. Mexiletine is administered orally and is currently approved for use in several countries.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers after oral administration.
References
Vozeh, S, et al., & Follath, F (1982). Population pharmacokinetic parameters in patients treated with oral mexiletine. European journal of clinical pharmacology 23(5) 445–451. DOI:10.1007/BF00605996 PUBMED:https://pubmed.ncbi.nlm.nih.gov/7151850
Kobayashi, M, et al., & Ueno, K (2006). Effect of congestive heart failure on mexiletine pharmacokinetics in a Japanese population. Biological & pharmaceutical bulletin 29(11) 2267–2269. DOI:10.1248/bpb.29.2267 PUBMED:https://pubmed.ncbi.nlm.nih.gov/17077526
Ueno, K, et al., & Shibakawa, M (2002). Evaluation of mexiletine clearance in a Japanese population. The Annals of pharmacotherapy 36(2) 241–245. DOI:10.1345/aph.10188 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11847941
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)