modelC01CA04
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Dopamine | |
| ATC code: | C01CA04 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 2.5 | mg |
| volume of distribution: | 0.11 | L |
| clearance: | 1.8 | L/min |
| other parameters in model implementation | ||
Dopamine is an endogenous catecholamine neurotransmitter that acts as a nonselective agonist at dopamine, alpha, and beta adrenergic receptors. It is primarily used as a vasopressor and inotropic agent in the treatment of shock, particularly cardiogenic and septic shock, and sometimes in advanced heart failure. Dopamine is an approved drug used in clinical settings.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult volunteers after intravenous infusion.
References
MacGregor, DA, et al., & Scuderi, PE (2000). Pharmacokinetics of dopamine in healthy male subjects. Anesthesiology 92(2) 338–346. DOI:10.1097/00000542-200002000-00013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10691218
Banner, W, et al., & Dean, JM (1991). Nonlinear dobutamine pharmacokinetics in a pediatric population. Critical care medicine 19(7) 871–873. DOI:10.1097/00003246-199107000-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2055074
Kwa, A, et al., & Jelliffe, RW (2008). A population pharmacokinetic model of epidural lidocaine in geriatric patients: effects of low-dose dopamine. Therapeutic drug monitoring 30(3) 379–389. DOI:10.1097/FTD.0b013e3181778fa3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18520611
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)