modelC01CA04_1
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Dopamine_1 | |
| ATC code: | C01CA04_1 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 5 | mg |
| volume of distribution: | 0.2 | L |
| clearance: | 1.5 | L/min |
| other parameters in model implementation | ||
Dopamine is an endogenous catecholamine neurotransmitter used as a vasopressor and inotropic agent in the treatment of shock and advanced heart failure. It acts on dopamine and adrenergic receptors and is approved for clinical use.
Pharmacokinetics
Estimated/typical pharmacokinetic parameters for intravenous infusion in adult patients, as referenced in clinical practice and secondary pharmacology textbooks.
References
MacGregor, DA, et al., & Scuderi, PE (2000). Pharmacokinetics of dopamine in healthy male subjects. Anesthesiology 92(2) 338–346. DOI:10.1097/00000542-200002000-00013 PUBMED:https://pubmed.ncbi.nlm.nih.gov/10691218
Banner, W, et al., & Dean, JM (1991). Nonlinear dobutamine pharmacokinetics in a pediatric population. Critical care medicine 19(7) 871–873. DOI:10.1097/00003246-199107000-00008 PUBMED:https://pubmed.ncbi.nlm.nih.gov/2055074
Kwa, A, et al., & Jelliffe, RW (2008). A population pharmacokinetic model of epidural lidocaine in geriatric patients: effects of low-dose dopamine. Therapeutic drug monitoring 30(3) 379–389. DOI:10.1097/FTD.0b013e3181778fa3 PUBMED:https://pubmed.ncbi.nlm.nih.gov/18520611
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)