modelC01CE01
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Amrinone | |
| ATC code: | C01CE01 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 15 | mg |
| volume of distribution: | 0.7 | L |
| clearance: | 4.6 | ml/min/kg |
| other parameters in model implementation | ||
Amrinone is a phosphodiesterase III inhibitor with inotropic and vasodilatory effects, formerly used in the management of congestive heart failure. It increases cardiac contractility and induces vasodilation. Due to safety concerns (notably thrombocytopenia), its use has largely been superseded by other agents and it is not commonly used in clinical practice today.
Pharmacokinetics
Pharmacokinetics in adult patients with congestive heart failure after intravenous administration.
References
Allen-Webb, EM, et al., & Banner, W (1994). Age-related amrinone pharmacokinetics in a pediatric population. Critical care medicine 22(6) 1016–1024. DOI:10.1097/00003246-199406000-00022 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8205809
Bailey, JM, et al., & Hug, CC (1991). Pharmacokinetics of amrinone during cardiac surgery. Anesthesiology 75(6) 961–968. DOI:10.1097/00000542-199112000-00006 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1741517
Eason, CT, et al., & Bonner, FW (1988). The relationship between the pharmacokinetics of amrinone in the marmoset and platelet effects. European journal of drug metabolism and pharmacokinetics 13(2) 129–133. DOI:10.1007/BF03191314 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3145204
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)