modelC03DA04
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Eplerenone | |
| ATC code: | C03DA04 | route: | oral |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 43.6 | L |
| clearance: | 10.8 | L/h |
| other parameters in model implementation | ||
Eplerenone is a selective aldosterone receptor antagonist used primarily for the treatment of hypertension and heart failure. It blocks the effects of aldosterone on the kidneys, promoting the excretion of sodium and water while retaining potassium. The drug is approved and widely used in clinical practice for managing cardiovascular conditions.
Pharmacokinetics
Pharmacokinetic parameters reported in healthy adult male volunteers after a single oral dose.
References
Oishi, M, et al., & Sweeney, K (2017). Population Pharmacokinetics of Eplerenone in Japanese Patients With Chronic Heart Failure. Journal of clinical pharmacology 57(6) 730–738. DOI:10.1002/jcph.861 PUBMED:https://pubmed.ncbi.nlm.nih.gov/28032902
Chen, J, et al., & Ruan, Z (2016). Dose Proportionality and Pharmacokinetics of Eplerenone in Healthy Chinese Subjects. Drug research 66(3) 154–159. DOI:10.1055/s-0035-1559623 PUBMED:https://pubmed.ncbi.nlm.nih.gov/26262771
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)