modelC07AA07
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Sotalol | |
| ATC code: | C07AA07 | route: | oral |
| compartments: | 1 | |
| dosage: | 160 | mg |
| volume of distribution: | 2.1 | L |
| clearance: | 0.13 | L/h/kg |
| other parameters in model implementation | ||
Sotalol is a non-selective beta-adrenergic blocker with class III antiarrhythmic properties, used for the treatment of ventricular and supraventricular arrhythmias, including atrial fibrillation and ventricular tachycardia. It is approved and widely used today for rhythm control in various arrhythmias.
Pharmacokinetics
Pharmacokinetic parameters for healthy adult subjects, following oral administration.
References
Yellepeddi, VK, et al., & Watt, K (2025). Population Pharmacokinetics and Pharmacodynamics of Sotalol Following Expedited Intravenous Loading in Patients With Atrial Arrhythmias. CPT: pharmacometrics & systems pharmacology 14(4) 658–667. DOI:10.1002/psp4.13302 PUBMED:https://pubmed.ncbi.nlm.nih.gov/39749676
Saul, JP, et al., & Hinderling, PH (2001). Pharmacokinetics and pharmacodynamics of sotalol in a pediatric population with supraventricular and ventricular tachyarrhythmia. Clinical pharmacology and therapeutics 69(3) 145–157. DOI:10.1067/mcp.2001.113795 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11240979
Saul, JP, et al., & Hinderling, PH (2001). Single-dose pharmacokinetics of sotalol in a pediatric population with supraventricular and/or ventricular tachyarrhythmia. Journal of clinical pharmacology 41(1) 35–43. DOI:10.1177/00912700122009818 PUBMED:https://pubmed.ncbi.nlm.nih.gov/11144992
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)