modelC09AA01
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Captopril | |
| ATC code: | C09AA01 | route: | oral |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 0.7 | L |
| clearance: | 40 | L/h |
| other parameters in model implementation | ||
Captopril is an angiotensin-converting enzyme (ACE) inhibitor used in the management of hypertension, congestive heart failure, diabetic nephropathy, and post-myocardial infarction. It is an approved drug currently used in clinical practice.
Pharmacokinetics
Healthy adult volunteers (both sexes), single oral dose, fasting state.
References
Pereira, CM, et al., & Collins-Nakai, RL (1991). The pharmacokinetics of captopril in infants with congestive heart failure. Therapeutic drug monitoring 13(3) 209–214. DOI:10.1097/00007691-199105000-00004 PUBMED:https://pubmed.ncbi.nlm.nih.gov/1926273
DiBianco, R (1986). Adverse reactions with angiotensin converting enzyme (ACE) inhibitors. Medical toxicology 1(2) 122–141. DOI:10.1007/BF03259832 PUBMED:https://pubmed.ncbi.nlm.nih.gov/3023783
Creasey, WA, et al., & Sugerman, AA (1986). Pharmacokinetics of captopril in elderly healthy male volunteers. Journal of clinical pharmacology 26(4) 264–268. DOI:10.1002/j.1552-4604.1986.tb03521.x PUBMED:https://pubmed.ncbi.nlm.nih.gov/3517077
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)