modelD01AA01
Extends from Pharmacokinetic.Models.PK_1C_enteral.
Information
| name: | Nystatin | |
| ATC code: | D01AA01 | route: | oral |
| compartments: | 1 | |
| dosage: | 500000 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0 | L/hr |
| other parameters in model implementation | ||
Nystatin is a polyene antifungal medication primarily used for the treatment of candidiasis of the skin, oral cavity, and gastrointestinal tract. It is not absorbed from the gastrointestinal tract or intact skin and is mainly used topically or orally (for local action). Nystatin is approved for medical use and is commonly used today for superficial fungal infections.
Pharmacokinetics
Nystatin administered orally in healthy adults. It is not systemically absorbed, and thus, pharmacokinetic parameters such as bioavailability, volume of distribution, and clearance are not measurable in plasma. Used for local action in the GI tract.
References
Bender, JF, et al., & Wiernik, PH (1979). Role of vancomycin as a component of oral nonabsorbable antibiotics for microbial suppression in leukemic patients. Antimicrobial agents and chemotherapy 15(3) 455–460. DOI:10.1128/AAC.15.3.455 PUBMED:https://pubmed.ncbi.nlm.nih.gov/464573
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.TransferRate | ka (from PK_1C_enteral) | 0.016666666666666666 | first order absorption rate |
| Modelica.Units.SI.Time | Tlag (from PK_1C_enteral) | 600 | delay between oral administration and absorption (default 10min) |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)