modelD01AC15_1
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Fluconazole_1 | |
| ATC code: | D01AC15_1 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 400 | mg |
| volume of distribution: | 41 | L |
| clearance: | 1.11 | L/h |
| other parameters in model implementation | ||
Fluconazole is a triazole antifungal medication used to treat and prevent a variety of fungal and yeast infections, including candidiasis and cryptococcal meningitis. It is approved for use in many countries and is commonly prescribed both for systemic and superficial mycoses.
Pharmacokinetics
Pharmacokinetic parameters as reported in healthy adult volunteers after single intravenous dose.
References
Tanzawa, A, et al., & Yamatani, A (2022). Fluconazole Population Pharmacokinetics after Fosfluconazole Administration and Dosing Optimization in Extremely Low-Birth-Weight Infants. Microbiology spectrum 10(2) e0195221–None. DOI:10.1128/spectrum.01952-21 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35266811
Wang, H, et al., & Li, X (2024). Population pharmacokinetics of fluconazole for prevention or treatment of invasive candidiasis in Chinese young infants. Naunyn-Schmiedeberg's archives of pharmacology 397(11) 8853–8862. DOI:10.1007/s00210-024-03184-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/38850301
Momper, JD, et al., & Benjamin, DK (2016). Population Pharmacokinetics of Fluconazole in Premature Infants with Birth Weights Less than 750 Grams. Antimicrobial agents and chemotherapy 60(9) 5539–5545. DOI:10.1128/AAC.00963-16 PUBMED:https://pubmed.ncbi.nlm.nih.gov/27401564
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)