modelD01AE06
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | D_24ChlorphenoxyEthanol | |
| ATC code: | D01AE06 | route: | topical |
| compartments: | 1 | |
| dosage: | 100 | mg |
| volume of distribution: | 5 | L |
| clearance: | 10 | L/h |
| other parameters in model implementation | ||
2-(4-chlorophenoxy)-ethanol is an antifungal agent historically used in topical treatments for skin mycoses. It is included in the ATC system under code D01AE06 as a dermatological antifungal. Its application has been mostly topical; the agent is not widely used today and has largely been replaced by other drugs. It is not currently approved for systemic use.
Pharmacokinetics
No published pharmacokinetic studies of 2-(4-chlorphenoxy)-ethanol in humans or animals were found. The following parameters are theoretical estimates for an average adult based on general properties of similar small-molecule topical antifungals.
References
Jin, N, et al., & Müller, RH (2019). Azithromycin nanocrystals for dermal prevention of tick bite infections. Die Pharmazie 74(5) 277–285. DOI:10.1691/ph.2019.8169 PUBMED:https://pubmed.ncbi.nlm.nih.gov/31109397
Baynes, RE, et al., & Riviere, JE (2002). Analysis of N,N-diethyl-m-toluamide in porcine skin perfusates using solid-phase extraction disks and reversed-phase high-performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 780(1) 45–52. DOI:10.1016/s1570-0232(02)00412-9 PUBMED:https://pubmed.ncbi.nlm.nih.gov/12383479
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)