modelD01AE14
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Ciclopirox | |
| ATC code: | D01AE14 | route: | topical |
| compartments: | 1 | |
| dosage: | 50 | mg |
| volume of distribution: | 1 | L |
| clearance: | 0.04 | L/h/kg |
| other parameters in model implementation | ||
Ciclopirox is a synthetic antifungal agent used topically to treat superficial fungal infections of the skin and nails, such as dermatophytoses, candidiasis, and tinea versicolor. It is approved for clinical use in many countries, primarily for topical application as creams, lotions, gels, and lacquers.
Pharmacokinetics
Pharmacokinetic parameters estimated for topical ciclopirox in healthy adults, as available literature does not provide detailed systemic PK measurements due to its minimal systemic absorption.
References
Gupta, AK, et al., & Foley, KA (2014). Topical therapy for toenail onychomycosis: an evidence-based review. American journal of clinical dermatology 15(6) 489–502. DOI:10.1007/s40257-014-0096-2 PUBMED:https://pubmed.ncbi.nlm.nih.gov/25257931
Hafeez, F, et al., & Maibach, H (2014). Ciclopirox delivery into the human nail plate using novel lipid diffusion enhancers. Drug development and industrial pharmacy 40(6) 838–844. DOI:10.3109/03639045.2013.788016 PUBMED:https://pubmed.ncbi.nlm.nih.gov/23600655
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)