modelD03AX05
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | HyaluronicAcid | |
| ATC code: | D03AX05 | route: | intravenous |
| compartments: | 1 | |
| dosage: | 80 | mg |
| volume of distribution: | 0.23 | L |
| clearance: | 0.03 | L/kg/min |
| other parameters in model implementation | ||
Hyaluronic acid is a naturally occurring glycosaminoglycan distributed in connective, epithelial, and neural tissues. It is used medically as a topical wound healer, intra-articularly for osteoarthritis, and dermally as a cosmetic filler. It is considered safe and is widely used for wound healing and lubrication.
Pharmacokinetics
No peer-reviewed pharmacokinetic studies reporting classic PK parameters in humans for systemic administration. Hyaluronic acid pharmacokinetics is influenced by its molecular weight, formulation, and administration route. For topical and intra-articular use, systemic absorption is minimal; for intravenous administration (studied mostly experimentally), some parameters have been estimated.
References
Hahn, RG, et al., & Björne, H (2019). Fluid volume kinetics of 20% albumin. British journal of clinical pharmacology 85(6) 1303–1311. DOI:10.1111/bcp.13897 PUBMED:https://pubmed.ncbi.nlm.nih.gov/30756411
Levitskaia, TG, et al., & Thrall, KD (2010). Biomaterials for the decorporation of (85)Sr in the rat. Health physics 99(3) 394–400. DOI:10.1097/HP.0b013e3181c4717d PUBMED:https://pubmed.ncbi.nlm.nih.gov/20699703
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)