modelD06AX12
Extends from Pharmacokinetic.Models.PK_2C.
Information
| name: | Amikacin | |
| ATC code: | D06AX12 | route: | intravenous |
| compartments: | 2 | |
| dosage: | 500 | mg |
| volume of distribution: | 16.1 | L |
| clearance: | 4.3 | L/h |
| other parameters in model implementation | ||
Amikacin is an aminoglycoside antibiotic used primarily for the treatment of severe bacterial infections caused by Gram-negative bacteria, including those resistant to other aminoglycosides. It is approved and commonly used today, mainly in hospital settings for serious infections such as sepsis, pneumonia, urinary tract infections, and intra-abdominal infections.
Pharmacokinetics
Pharmacokinetic parameters reported for adult patients with normal renal function receiving intravenous infusion.
References
Severino, N, et al., & Paredes, N (2023). Population pharmacokinetics of amikacin in suspected cases of neonatal sepsis. British journal of clinical pharmacology 89(7) 2254–2262. DOI:10.1111/bcp.15697 PUBMED:https://pubmed.ncbi.nlm.nih.gov/36811146
Medellín-Garibay, SE, et al., & García, B (2022). Amikacin pharmacokinetics in elderly patients with severe infections. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 175 106219–None. DOI:10.1016/j.ejps.2022.106219 PUBMED:https://pubmed.ncbi.nlm.nih.gov/35618200
Bressolle, F, et al., & Gomeni, R (1996). Population pharmacokinetics of amikacin in critically ill patients. Antimicrobial agents and chemotherapy 40(7) 1682–1689. DOI:10.1128/AAC.40.7.1682 PUBMED:https://pubmed.ncbi.nlm.nih.gov/8807062
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
| Pharmacolibrary.Types.Volume | Vdp (from PK_2C) | VdpPerKg*weight | Volume of distribution (m3) |
| Modelica.Units.SI.SpecificVolume | VdpPerKg (from PK_2C) | 0.9 | Volume of distribution peripheral(l/kg) |
| Pharmacolibrary.Types.Clearance | k12 (from PK_2C) | 1 | intercompartmental C-P clearance |
| Pharmacolibrary.Types.Clearance | k21 (from PK_2C) | 1 | intercompartmental P-C clearance |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | peripheralCPort (from PK_2C) | ||
| Pharmacolibrary.Types.ConcentrationOutput | C_peripheral1 (from PK_2C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life | |
| Pharmacolibrary.Pharmacokinetic.TransferFirstOrderNonSym | transfer (from PK_2C) | ||
| Pharmacolibrary.Pharmacokinetic.NoPerfusedTissueCompartment | peripheral (from PK_2C) |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)