modelD07AD01
Extends from Pharmacokinetic.Models.PK_1C.
Information
| name: | Clobetasol | |
| ATC code: | D07AD01 | route: | topical |
| compartments: | 1 | |
| dosage: | 0.05 | mg |
| volume of distribution: | 2.5 | L |
| clearance: | 15 | L/h |
| other parameters in model implementation | ||
Clobetasol is a super-high potency synthetic corticosteroid used topically for the treatment of severe dermatoses such as psoriasis, eczema, and lichen planus. It is available as creams, ointments, and solutions and is approved for use in many countries.
Pharmacokinetics
Pharmacokinetic parameters are based on estimated and indirect data due to the lack of published human PK studies. Clobetasol is typically applied topically, and systemic absorption in healthy adults is minimal except under occlusion or on damaged skin.
References
Badıllı, U, et al., & Tarımcı, N (2011). Microparticulate based topical delivery system of clobetasol propionate. AAPS PharmSciTech 12(3) 949–957. DOI:10.1208/s12249-011-9661-7 PUBMED:https://pubmed.ncbi.nlm.nih.gov/21748539
Tsai, JC, et al., & Chou, CH (2004). Evaluation of in vivo bioequivalence methodology for topical clobetasol 17-propionate based on pharmacodynamic modeling using Chinese skin. Journal of pharmaceutical sciences 93(1) 207–217. DOI:10.1002/jps.10536 PUBMED:https://pubmed.ncbi.nlm.nih.gov/14648650
Parameters
| Type | Name | Default | Description |
|---|---|---|---|
| Modelica.Units.SI.Mass | weight (from PK_1C) | 75 | patient weight (kg) |
| Modelica.Units.SI.SpecificVolume | VdPerKg (from PK_1C) | 0.9 | Volume of distribution (L/kg) |
| Modelica.Units.SI.MassFraction | F (from PK_1C) | 0.8 | bioavailiability (0-1) |
| Pharmacolibrary.Types.Clearance | Cl (from PK_1C) | 20 | clearance |
| Modelica.Units.SI.Time | adminTime (from PK_1C) | 60 | first administration time (s) |
| Modelica.Units.SI.Time | adminDuration (from PK_1C) | 600 | administration duration (s) |
| Modelica.Units.SI.Time | adminPeriod (from PK_1C) | 8*60*60 | period of administration (default 8 hours)(s) |
| Pharmacolibrary.Types.Mass | adminMass (from PK_1C) | 1000 | administration mass (mg) |
| Integer | adminCount (from PK_1C) | 8 | number of dose administered (1) |
| Pharmacolibrary.Types.Volume | Vd (from PK_1C) | VdPerKg*weight | Volume of distribution (m3) |
| Pharmacolibrary.Types.MassConcentration | Cmin (from PK_1C) | 0.004 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Cmax (from PK_1C) | 0.008 | minimal therapeutic range |
| Pharmacolibrary.Types.MassConcentration | Ctox_peak (from PK_1C) | 0.012 | toxicity peak level |
| Pharmacolibrary.Types.MassConcentration | Ctox_trough (from PK_1C) | 0.006 | toxicity trough level |
Connectors
| Type | Name | Default | Description |
|---|---|---|---|
| Types.ConcentrationOutput | C_central (from PK_1C) | ||
| Interfaces.ConcentrationPort_b | centralCPort (from PK_1C) |
Components
| Type | Name | Default | Description |
|---|---|---|---|
| Pharmacokinetic.NoPerfusedTissueCompartment | central (from PK_1C) | ||
| Pharmacokinetic.ClearanceDrivenElimination | elim (from PK_1C) | ||
| Sources.PeriodicDose | periodicDose (from PK_1C) | ||
| Modelica.Units.SI.Time | t1_2 (from PK_1C) | elimination half-life |
Revisions
- 06/2025 Tomas Kulhanek, generated model from data extracted from PUBMED, DrugBank and LLM(GPT4.1)